Identification of lysocin E using a silkworm model of bacterial infection.
نویسندگان
چکیده
New antimicrobials with novel mechanisms need to be developed to combat antimicrobial-resistant pathogenic bacteria. The current authors recently reported discovery of a new antibiotic named "Lysocin E". Lysocin E was identified using a silkworm model of bacterial infection. The current review discusses the advantages of using a silkworm model of bacterial infection to identify and develop therapeutically efficacious antimicrobials. This review also discusses the discovery of lysocin E and its novel mechanism of action.
منابع مشابه
Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane.
To obtain therapeutically effective new antibiotics, we first searched for bacterial culture supernatants with antimicrobial activity in vitro and then performed a secondary screening using the silkworm infection model. Through further purification of the in vivo activity, we obtained a compound with a previously uncharacterized structure and named it 'lysocin E'. Lysocin E interacted with mena...
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ورودعنوان ژورنال:
- Drug discoveries & therapeutics
دوره 10 1 شماره
صفحات -
تاریخ انتشار 2016